Dysregulation of NF-κB activation has a significant effect on the development of hepatic steatosis and inflammation, and inhibition of NF-κB ameliorates inflammatory infiltration in the liver of NASH mice (Romics et al., 2004; Locatelli et al., 2013; Rom et al., 2020). This evidence concerns the gene NFKB1 and Hepatic steatosis.