In this study, under the treatment of Ganweikang tablets, the levels of Ccl2 and Ccr2 in the liver of the NAFL mice were reduced, accompanied by a decrease in the expression of the pro-inflammatory factor TNF-α, which accounts for decreased macrophages infiltration and reducing inflammation in the liver of NAFL and NASH mice. The gene discussed is CCL2; the disease is metabolic dysfunction-associated steatohepatitis.