In addition to the crucial role in the regulation of inflammatory response, hyperactivation of IKKs/NF-κB pathway has been shown to inhibit tumor apoptosis and promote tumor proliferation and invasion (Perkins, 2012), which indicated that the anti-cancer effect of brevilin A is due, at least in part, to its suppression on IKKα/β. The gene discussed is NFKB1; the disease is neoplasm.