Herein, we found that brevilin A effectively inhibits LPS/interferon-γ (IFNγ)- or TNFα/IFNγ-induced inflammatory response in RAW264.7 macrophages and bone-marrow derived macrophages (BMDMs) in vitro, as well as LPS-induced ALI in vivo. This evidence concerns the gene IFNG and acute respiratory distress syndrome.