The c-kit (CD117) receptor is widely expressed in the cytoplasm and membrane of ICC and regulates MAPK, PI3K/Akt, Wnt, and other signaling pathways by binding to its natural ligand SCF, which determines the differentiation and function of ICC (Gibbons et al., 2007). This evidence concerns the gene AKT1 and intrahepatic cholangiocarcinoma.