The c-kit (CD117) receptor is widely expressed in the cytoplasm and membrane of ICC and regulates MAPK, PI3K/Akt, Wnt, and other signaling pathways by binding to its natural ligand SCF, which determines the differentiation and function of ICC (Gibbons et al., 2007). The gene discussed is PIK3CD; the disease is intrahepatic cholangiocarcinoma.