WB images showed that p-STAT3 and p-ERK were also inhibited at the protein level after IL-21R silencing, BAB lost its protective effect on ICC, the images of PARP, caspase-3, and caspase-9 were almost the same as those in the LOP group after BAB treatment, and the apoptotic rate was not reduced (Figures 9D,E). The gene discussed is CASP9; the disease is intrahepatic cholangiocarcinoma.