Recent studies have reported that ASP polysaccharides can inhibit hypoxia-induced hepatocellular carcinoma cell migration, invasion, and angiogenesis by regulating hypoxia inducible factor alpha (HIF-1α) and vascular endothelial growth factor (VEGF) expression through mitogen activated protein kinase (MAPK) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling pathways (Cheng et al., 2021). This evidence concerns the gene VEGFA and hepatocellular carcinoma.