Wang et al. (2019) indicated that blocking the TLR4/NOX2 signaling might be a potential therapy for endotoxin-induced cardiac dysfunction. Inhibition of NOX1/ROS prevented the enhancement of lung tumor burdens by LPS-induced acute lung infection in non-small cell lung cancer (NSCLC) cells (Liu et al., 2015). This evidence concerns the gene TLR4 and non-small cell lung carcinoma.