CSNK2B and Global developmental delay: CSNK2B was first reported by Poirier et al. (2017) in two individuals with early-onset epilepsy, developmental delay, hypotonia, and malformations, and was documented as the causative gene for POBINDS by OMIM in 2020.3 A total of 57 individuals with CSNK2B mutations have been reported to date (including eight cases in this article), and the largest sample study to date was published in Epilepsia by Ernst et al. (2021).