However, STN1, AFG1L, PLEKHB2, DHX36, WDR73, SDR39U1, MRS2, NSCME2, COMMD8, CCT6A, NBPF4, SCNK2B, MFSD11, SNF684, and C16orf72, are relatively unstudied in the context of neurodegenerative diseases and AD, raising the possibility of having identified novel mechanisms. This evidence concerns the gene COMMD8 and Alzheimer disease.