HDAC4 and Alzheimer disease: The full BioPlanet pathway list in Supplementary Table 4 also revealed numerous several entries for NOTCH signaling via the influence of HDAC4, a histone deacetylase with an important role in nerve function by promoting neuronal apoptosis (Bolger and Yao, 2005) and of interest as a therapeutic target for AD due to its deregulation and accumulation in the AD brain (Xu et al., 2011; Shen et al., 2016; Wu et al., 2016).