This “Alzheimer’s disease” pathway overlaps with other AV-1451-associated pathways that relate to mitochondrial respiration, electron transport, and oxidative phosphorylation (NDUFS4 & 8, NDUFA6 &7, UQCRQ, & COX17), as well as metabolism (NDUFS4 & 8, NDUFA6 &7, UQCRQ, COX17, & ETHE1). This evidence concerns the gene NDUFS4 and early-onset autosomal dominant Alzheimer disease.