Since BCL2, SPAG16, LRRC37A2, TGFBR2, ANKRD12, MYC, PXK, BTG1, EXT1, MYCBP2, and PAX5 are SE-associated genes, the roles of the genes SPAG16, LRRC37A2, ANKRD12, PXK, and BTG1 have not been illuminated in DLBCL, which merits further in-depth analysis in the wet laboratory. The gene discussed is LRRC37A2; the disease is diffuse large B-cell lymphoma.