Overexpression of TIM-3/HAVCR2 is associated with poor prognosis in squamous cell carcinoma, colorectal, renal cell carcinoma, gastric, and breast cancers (Shen et al., 2016; Wang et al., 2016; Wang et al., 2017; Stenzel, 2018). This evidence concerns the gene HAVCR2 and hereditary clear cell renal cell carcinoma.