Differential analysis of KEGG pathway enrichment in high- and low-risk groups revealed that the high-risk group was mainly enriched in the systemic lupus erythematosus, RIG l-like receptor signaling pathway, NOD-like receptor signaling pathway, cytoplasmic DNA sensing pathway, antigen processing and presentation, primary immunodeficiency, etc. pathways, while the low-risk group was mainly enriched in the lysine degradation, proximal tubule bicarbonate recovery, glycolytic gluconeogenesis, PPAR signal pathway, renin–angiotensin system, etc. pathways (Figure 7). The gene discussed is REN; the disease is systemic lupus erythematosus.