HIF1A and cancer: In addition, KEGG enrichment uncovered that HIF1A-regulated genes were involved in the “cancer pathway,” “HIF1 signaling pathway,” “PI3K-Akt signaling pathway,” “cancer,” “microRNAs in cancer,” and “P53 signaling pathway.” Furthermore, GO analysis revealed that HIF1A-regulated DEGs were mainly enriched in biological metabolic processes, cell membrane components, catalytic factor activity, transcription factor activity, and other cellular and biological functions (Figure 3C).