CCL2 and neoplasm: Furthermore, the chemokine CCL2 and nucleosome-binding protein HMGN5 were increased significantly since CCL2 plays a key role in tumor inflammation and HMGN5 might be the important regulators of gene expression in cells (Tang et al., 2012; Lin et al., 2013; Gonzalez-Romero et al., 2015; Liu et al., 2020).