Previous studies of extracellular vesicles from breast cancer cells reported that hsa-miR-4488 was negatively correlated to the mitochondrial calcium uniporter and that was related to the suppression of angiogenesis of vascular endothelial cells by acting on CX3CL1. Its absence or absent expression appeared to increase angiogenesis and favor metastasis in breast cancer cells (Zheng et al., 2020). The gene discussed is CX3CL1; the disease is breast cancer.