In AML, the hsa-miR-4488, hsa-miR-486-5p, and hsa-miR-5096 levels in the bone marrow were higher than were in ALL, hsa-miR-4488 and hsa-miR-4516 expressions correlated with HLA-G5 expression (p = 0.0008 and p = 0.0258, respectively), and the increased HLA-G5 expression correlated with low sHLA-G levels, but no miRNA expression correlated with the sHLA-G levels. The gene discussed is HLA-G; the disease is acute lymphoblastic leukemia.