High plasma HLA-G (sHLA-G) levels have been associated with immunosuppression and worse prognosis in several hematological malignancies, such as acute and chronic leukemias (Sebti et al., 2003; Gros et al., 2006; Rizzo et al., 2014; Caocci et al., 2017), Hodgkin’s lymphoma (Diepstra et al., 2008; Caocci et al., 2016), and diffuse large B-cell lymphoma (Josionek-Kupnicka et al., 2016). The gene discussed is HLA-G; the disease is hematologic disorder.