Since, in T-ALL, only high sHLA-G producers are associated with elevated blood cell count (dos Santos Almeida et al., 2018), this study was designed to clarify the relationship between the sHLA-G levels and the microRNA profiles in the bone marrow of untreated ALL patients to unveil some of the posttranscriptional control of HLA-G in leukemia. The gene discussed is HLA-G; the disease is leukemia.