It is further hypothesized that the NF-KB signaling pathway can be targeted to reduce the occurrence of inflammatory response and cytokine release, inhibit SARS-CoV-2 infection, and improve alveolar hypercoagulation and fibrinolytic inhibition in ARDS (Pooladanda et al., 2019; Yang et al., 2021) (Figure 1). The gene discussed is NFKB1; the disease is acute respiratory distress syndrome.