CCN3 and Alzheimer disease: Despite their pro-inflammatory role, melanocytes might be involved in inflammatory diminishing, as suggested by overexpressing matricellular protein CCN family member 3 (CCN3, limiting proinflammatory activation) (45), SERPINF1 (antiangiogenic factor) (46), and Annexin A1 (ANXA1, an anti-inflammatory factor functioning as a major mediator of glucocorticoid responses) in AD (7, 47).