RIPK1 and keloid: Our present experiment showed that NaHS pretreatment downregulated the expression of RIPK1 and RIPK3, inhibited MLKL phosphorylation, and decreased the TUNEL staining-positive rate in keloid fibroblasts and TGF-β1-stimulated normal skin fibroblasts, suggesting that exogenous H2S supplementation alleviated necroptosis in both keloid fibroblasts and TGF-β1-stimulated normal skin fibroblasts.