The aim of the current work was to search for and to experimentallyverify in vitro the effects of unannotated SNPsin TATA boxes within promoters of genes NOS1, GRIN1, andASCL3 (which are involved in neuropsychiatric disordersand cancers) on the affinity and kinetic characteristics ofTBP–TATA complexes. The gene discussed is GRIN1; the disease is cancer.