Already in 2018, the ClinVar database (Landrum et al.,2016) included 4973 variants of the LDLR gene (Iacocca etal., 2018) associated with FH, of which 2351 variants wereclassified as pathogenic, and 1525 as probably pathogenic,the rest considered as benign variants or variants of uncertainclinical significance. The gene discussed is LDLR; the disease is familial hyperaldosteronism.