ARL4C and renal carcinoma: To further verify that the Wnt/β-catenin signaling pathway regulates the protein expression of ARL4C in renal cancer cells, we cultured 786-O and ACHN cells with or without Wnt agonist 1 (Wnt agonist 1+/−) and ARL4C knockdown (si-ARL4C/si-NC).