OCA → ↑ FXR and BSEP, ↓ LPS‐induced hepatocyte apoptosis and inflammatory infiltration, ↓ ALT, AST, TBA and TB,↓ IL‐1β, TNF‐α, IL‐6 → ↓ bile acid synthesis; stimulated ATF4‐mediated autophagy activity. The gene discussed is IL6; the disease is tuberculosis.