We finally performed alteration analysis of eight hub genes which showed significant effects on survival analysis, including CDK1, CCNB1, CCNA2, AURKA, MAD2L1, NCAPG, DLGAP5, and CENPE. The result showed that more than 40% of the patient tumours analysed had at least one hub gene alteration. Here, CCNA2 is linked to neoplasm.