Our results showed that overexpression of six hub genes influenced COAD prognosis, including CCNB1, CCNA2, AURKA, NCAPG, DLGAP5, and CENPE. Overexpression of the six genes was associated with favourable overall survival (OS) of colon cancer patients (Figures 5(a)–5(f)). The gene discussed is CENPE; the disease is malignant colon neoplasm.