The molecular mechanism underlying thiseffect was shown to be dependent on specific and distinct interactionsbetween the S protein and LPS, enabling LPS’s transfer to CD14and subsequent downstream NF-κB activation.12 The resulting synergism between the S protein and LPS hasclinical relevance, providing new insights into comorbidities thatmay increase the risk for ARDS during COVID-19. This evidence concerns the gene NFKB1 and COVID-19.