LGALS3BP and periventricular nodular heterotopia: Another key gene that has been recently described to be enriched in human bRG (Pollen et al., 2015), while being linked to periventricular nodular heterotopia, is LGALS3BP. Studies using organoids showed that LGALS3BP expression is essential for proper positioning of bRG, whereas altered LGALS3BP expression resulted in neuronal heterotopia and defects in local gyrification, emphasising once again a potential role of bRG in disease (Kyrousi et al., 2021).