Likewise, self-sustained YAP activity has been found in CAFs, through mutually enhanced cell contractility and “inside-out” ECM stiffening, to remodel the niche mechano-environment (i.e., the tumor microenvironment (TME)), thereby promoting tumor progression (Calvo et al., 2013; Piccolo et al., 2014). This evidence concerns the gene YAP1 and neoplasm.