In the DKD study, SIRT1 regulated podocyte fatty acid synthesis via AMPK-SREBP1 (92), podocyte inflammation by AMPK-NFκB (90), glucolipid metabolism, and mitochondrial function by AMPK-PGC1α (82), fibronectin in mesangial matrix deposition (94), and protein synthesis and mesangial cell hypertrophy through AMPK-mTOR (97). The gene discussed is PPARGC1A; the disease is diabetic kidney disease.