SIRT1 induces glomerular extracellular matrix proliferation and changes of Collagen type IV (ET-1), Collagen 1α, and non-collagenous glycoprotein, Fibronectin, via TGFβ1/Smad pathway in early DKD (65, 66, 69, 77). The gene discussed is FN1; the disease is diabetic kidney disease.