They hypothesised that the role of TEX101 in cancer progression is due to its possible effect in reducing the function of uPAR, MMPs and cathepsin B. Loss of TEX101 and therefore gain of function of these enzymes could lead to increased cell proliferation and migration of cancer cells in head and neck squamous cell carcinoma as well as in TGCT (47, 50). Here, PLAUR is linked to head and neck squamous cell carcinoma.