Although Xiaofeng Jin et al. have found that CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling, whether SPOP plays essential functions in hematologic malignancies still remains undefinited [27]. Here, NFKB1 is linked to diffuse large B-cell lymphoma.