We also detected the SPOP levels and found that SPOP expressed lowly in DLBCL versus normal tissues based on the GSE83632 data set (N = 164) in Fig. 4A. Kaplan–Meier analysis in GSE83632 data set also indicated that patients with low SPOP levels suffered from poor prognosis relative to those with high SPOP levels (Fig. 4B). The gene discussed is SPOP; the disease is diffuse large B-cell lymphoma.