FOXP3 and type 1 diabetes mellitus: Of interest, by searching the Gene and Autoimmune Disease Association Database (GAAD) [32], we obtained 245 annotated genes that are associated with T1D, and found a significant enrichment of FOXP3 binding sites in T1D-associated genes (Fisher exact test: P-value = 4.519e-09), suggesting a strong association between T1D risk and FOXP3 controlled Treg function.