ELMO1 and systemic sclerosis: Of the variants identified by 3DFAACTS-SNP, one variant (rs60600003) located at a locus on chromosome 7 was found to be associated with several diseases, including MS [65], celiac and systemic sclerosis [66], suggesting its interacting gene, ELMO1, may contribute to a common Treg defect in these diseases (Additional file 3: Table S9).