While different variants were identified in the analysis of the various disease datasets, the regulatory elements in which these variants reside can be linked by Hi-C data to common candidate target gene such as PFKFB3 (rs12722496 from T1D and rs947474 from 4AI) and RAPH1 (rs231775 from T1D and rs3087243 from 4AI). The gene discussed is PFKFB3; the disease is type 1 diabetes mellitus.