Significantly, the unusual accumulation of p62 has been identified in certain cancers such as hepatocellular carcinoma [64], lung [65, 66], gastric [67, 68], breast [69, 70], and colon cancers [67, 71], which might increase the malignant behavior of these tumors through improving Nrf2 activity. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.