For example, miR-7,miR-200a and miR-141 that are overexpressed in neuroblastoma, breast and ovarian cancer, respectively, down-regulate Keap1 expression through binding to the 3′-untranslated region (3′-UTR) of Keap1 mRNA [54–56], while inhibition of miR-200a results in up-regulation of Keap1 and subsequently reduction in Nrf2 activation [54]. Here, KEAP1 is linked to ovarian carcinoma.