FADS2 and obesity due to melanocortin 4 receptor deficiency: Since the majority of studies which have documented a protective role for dietary NEAC against obesity [10] and other health outcomes such as MetS [60], cancers [13] and T2D [12], it is not surprising that high intakes of NEAC neutralize detrimental effects of greater genetic predisposition to cardio-metabolic risk factors in FADS2 minor allele carriers that this means these individuals are more likely to respond to high intakes of dietary antioxidants.