Moreover, according to the criteria of GS > 0.6 and MM > 0.9, 11 genes were identified as hub genes in the TB module, including GBP1, HLA-B, ELF4, HLA-E, IFITM2, TNFRSF14, CD274, AIM2, CFB, RHOG, and HORMAD1. Among them, HLA-B and HLA-E belong to the major histocompatibility complex class I protein complex and are involved in the presentation of foreign antigens to CD8( +) T cells in TB21,22. The gene discussed is CD8A; the disease is tuberculosis.