In the non-D-positive cases without cGAS expression as shown in the upper panels of Fig. 2a, only a small number of cytotoxic CD8 + T cells were observed, while in the D-positive cases expressing both cGAS and STING, a large number of cytotoxic CD8 + T cells infiltrated the vicinity and inside of the tumor in many cases compared to non-D-positive cases (Fig. 2a, lower panels). This evidence concerns the gene CD8A and neoplasm.