Moreover, co-deletion of PTEN and α6- or β4-integrin in DU145 cells, a PCa cell line that is heterozygous for functional PTEN, phenocopied PC3-α6-KO and PC3-β4-KO cells confirming that HD disruption in PTEN-negative cells induces FA-mediated signaling, cell proliferation and migration (Fig. 3I–K). This evidence concerns the gene PTEN and posterior cortical atrophy.