ITGA6 and metastatic malignant neoplasm in the lymph nodes: Importantly, high PLEC levels and lymph node metastasis (Fig. 7P), Gleason score (Fig. 7I, O), PSA level (Fig. 7N), and metastasis (Fig. 7H, R) all were positively correlated in double stratified ITGB4 or ITGA6 low, and PTEN low or PTEN copy loss number patients’ groups.