YAP1 and cancer: Invadopodia were scarcely observed in two cancer cell lines (MCF7 and MCF-10A) with YAP1 low expression and T47D cells with YAP1 cytoplasmic retention, and were quite common in MDA-MB-231 and MDA-MB-468 cells with relatively high YAP1 expression and nuclear localization (Fig. 1B).