m.10237T>C mutation which causes an amino acid change from isoleucine to threonine at position 60 (Ile60Thr) within the MT-ND3 gene is a rare LHON mutation, reported in two Hungarian siblings with LHON patients lacking the three most common pathogenic DNA mutations40. This evidence concerns the gene MT-ND3 and Leber hereditary optic neuropathy.