Further, a subset of five differentially methylated genes, namely Ubiquitin Specific Peptidase 22 (USP22), Chaperonin Containing TCP1 Subunit 7 (CCT7), RAN Binding Protein 3 (RANBP3), Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma (PIK3CG), and Protocadherin Gamma Subfamily B, 6 (PCDHGB6), overlapped with more than one T1D gene expression datasets that were from pancreatic and blood samples. The gene discussed is PIK3CG; the disease is type 1 diabetes mellitus.