After a final combined analysis, as shown in Table 1, JADE2 rs329118 T>C was found to be associated with a significantly decreased risk of lung cancer [odds ratio (OR) = 0.94, 95% confidence interval (CI) = 0.92–0.96, P = 8.80 × 10−9], while two other SNPs were associated with a significantly increased risk of lung cancer (GGA2 rs2285521 C>T: OR = 1.08, 95% CI = 1.05–1.11, P = 4.43 × 10−8 and MYRF rs198459 G>A: OR = 1.07, 95% CI = 1.04–1.11, P = 1.60 × 10−6). This evidence concerns the gene JADE2 and lung cancer.