We identified three genetic variants (rs329118, rs198459, and rs2285521) to be associated with lung cancer risk, residing in a gene for apoptosis and differentiation in epithelia 2 (JADE family PHD zinc finger 2; JADE2; PHF16) at 5q31.1, myelin regulatory factor gene (MYRF) at 11q12.2, and golgi-localized, γ-adaptin ear-containing, ADP ribosylation factor-binding protein 2 (GGA2) at 16p12.2, respectively. This evidence concerns the gene JADE2 and lung cancer.