METTL3 and familial pancreatic carcinoma: As a point that require attention in interpretation, we noted that the pancreatic tumors in mice indicated acinar cell carcinoma-like features, whereas human pancreatic cancer showed histology of ductal adenocarcinoma, implying that we studied the effect of METTL3 overexpression in vivo in a mouse model that was close to the spontaneous occurrence of tumors, and suggesting that PLK1 is a useful therapeutic target for pancreatic adenocarcinoma, which is refractory to treatment.