Among those candidates, IGF2BP2 was the only one associated with poor prognosis in patients with pancreatic adenocarcinoma at high expression levels (from TCGA, data not shown), and the highest correlation was observed between the pathological grade and PLK1 expression level, so IGF2BP2 was considered the most likely candidate of methylation leader proteins of the PLK1 3′UTR (Supplementary Fig. 6b). The gene discussed is PLK1; the disease is pancreatic adenocarcinoma.