The role of METTL3 in pancreatic cancer was first reported in our previous study, and although METTL3 is higher in pancreatic adenocarcinoma than in healthy pancreatic tissue and patients with high METTL3 levels have a poor clinical prognosis69, the detailed mechanism by which METTL3 methylates and regulates the expression of genes has not yet been elucidated in pancreatic adenocarcinoma. This evidence concerns the gene METTL3 and familial pancreatic carcinoma.