Since riluzole inhibited cell proliferation and colony formation, and induced apoptosis in vitro, we next sought to examine the effects of riluzole on pancreatic cancer growth and development in KPC (Pdx1-Cre, LSL-Trp53R172H, and LSL-KrasG12D) mice by treating them for three months. Here, PDX1 is linked to pancreatic neoplasm.