GPT and hypertensive disorder: We next tested the relationship between VATadj, ASATadj, and GFATadj polygenic scores and biomarkers of metabolic health (hemoglobin A1C, HDL cholesterol, serum triglycerides, and alanine aminotransferase (ALT)) and disease outcomes (type 2 diabetes, hypertension, and coronary artery disease) (Fig. 7 and Supplementary Data 20).