While we confirmed that HLA-ABC(−) ΔTRACCARΔB2MHLAE overcame alloresponsive T-cell attack, we demonstrated their ability to evade NK cells attack by the significant enrichment of HLA-ABC(−) HLA-E(+) ΔTRACCARΔB2MHLAE in the presence of primary NK cells from healthy donors and AML patients. Here, HLA-E is linked to acute myeloid leukemia.