In contrast, PD brain tissues displayed strong immunoreactivity of α-synuclein (Supplemental Fig. 1D–F) and pα-synucleinS129 (pα-synS129), an index of α-synuclein aggregates (Supplemental Fig. 1G–I), as previously reported [26, 39, 40]. The gene discussed is SNCA; the disease is Parkinson disease.