MMP1 and adenomyosis: In addition, mRNA levels of CXCL8 were also significantly increased in the myometrium of women with adenomyosis compared with controls (P = 0.044) (FIGURE 5C) without significant changes in either IL1B or TNF. On the contrary, MMP1 and MMP8 mRNAs were significantly increased in the myometrium of women with adenomyosis (P = 0.0005 and 0.021, respectively) (FIGURE 5D), similar to that observed in the endometrium of women with disease (FIGURE 3B).