Interestingly, PRL also functions as a growth factor for pancreatic beta cells via the JAK/STAT pathway (Nielsen et al., 1992) and induces glucose-stimulated insulin secretion and insulin production in rat islet beta cells during fetal (Møldrup et al., 1993; Freemark et al., 1995; Royster et al., 1995), neonatal (Brelje and Sorenson, 1991; Brelje et al., 1994), and adult development (Møldrup et al., 1993), suggesting PRL may partially mediate hyperinsulinemia during HS (Baumgard and Rhoads, 2013). This evidence concerns the gene PRL and Hyperinsulinemia.