ENTPD5 and COVID-19: For the main MR analysis in European ancestry, the genetically-predicted protein level of ENTPD5 showed a positive effect on COVID-19 severity after multiple testing correction (odds ratio [OR] of COVID-19 severity per standard deviation change of protein level= 2.07, 95%CI=1.47 to 2.92, P = 3.29 × 10−5; Table S8A) using data from HGI.