SERPINA1 showed an effect on COVID-19 severity in African ancestry using the GenOMICC v2 data (OR=0.481, 95%CI=0.345 to 0.673, P = 1.9 × 10−5), where the heterogeneity test suggested a distinct effect estimate of SERPINA1 across the two ancestries (P of pair-wise Z-score test=7.70 × 10−6; Table S8E). This evidence concerns the gene SERPINA1 and COVID-19.