SERPINA1 and COVID-19: For the main MR analysis in African ancestry, the genetically-predicted protein level of SERPINA1 showed a robust effect on COVID-19 severity in African ancestry (OR=0.369, 95%CI=0.203 to 0.668, P = 9.96 × 10−4), but showed little evidence of an effect in European ancestry (OR=1.021, 95%CI=0.901 to 1.157, P = 0.745; Figure 2).