Our omics MR and colocalization analysis of over 400K target-disease pairs identified putative causal effect of levels of six proteins on COVID-19 severity, where four of them, ENTPD5, OAS1, FCRL3, ICAM5, showed evidence of effects in European ancestry; SERPINA1, showed evidence of an effect in African ancestry, and ICAM1 showed evidence of a bi-ancestry effect. Here, SERPINA1 is linked to COVID-19.