Recent GWAS18,19,20 and MR studies21, 22, 23 utilising data from the COVID-19 Host Genetics Initiative (HGI; https://www.covid19hg.org/) and GenOMICC consortium19,24 have identified a set of genes (e.g. ABO, OAS1, IFNAR2, IL10RB) associated with various COVID-19 phenotypes. The gene discussed is OAS1; the disease is COVID-19.