Interleukin-2 (IL-2) and Interferon (IFN-γ) CD4+ and CD8+ T cell responses specific to SARS-CoV-2 spike (S), nucleocapsid (N) and membrane (M) peptides are detected in PCR-positive individuals up to 12 months after infection, including in those who are seronegative.20 The gene discussed is IFNG; the disease is infection.