So, the objectives of this study are to (i) analyze entire exonic regions of the GATA1 gene in dengue patients suffering from thrombocytopenia, (ii) identify the relationship between different variants of the GATA1 gene with thrombocytopenia, and (iii) elucidate the impact of variants on the three-dimensional structure of GATA1 followed by its function. This evidence concerns the gene GATA1 and dengue disease.