Among genes that could only be identified using splicing data, PICALM (MSG p-value = 1.93 × 10−9; S-PrediXcan p-value = 9.80 × 10−1) and PTK2B (MSG p-value = 7.96 × 10−9; S-PrediXcan p-value = 8.98 × 10−1) are two genes previously shown to be significantly differentially spliced between AD patients and healthy controls [17]. Here, PTK2B is linked to Alzheimer disease.