To understand the underlying mechanism of olfactory cilia shortening in BBS and investigate if lipid remolding occurs in olfactory cilia in vivo, we examined in a previous study the olfactory ciliary distribution of PI(4,5)P2 in a Bbs4 global knockout (Bbs4−/−) mouse model (referred to as Bbs4KO) (9). This evidence concerns the gene BBS4 and Bardet-Biedl syndrome.