IFT88 and ciliopathy: To further explore if PI(4,5)P2 ciliary mislocalization is a shared mechanism underlying olfactory dysfunction in ciliopathies, we investigated the PI(4,5)P2 ciliary distribution in different ciliopathies, including Bbs1M390R/M390R (homozygous for Bbs1M390R) and Ift88OSNKO (OSN-specific Ift88 knockout) mouse models, which all have shortened olfactory cilia (10, 14).