Overall, mean age, MELD score, lymphocyte count, NLR, TBIL, INR, CRP, IL-6, proportion of sarcopenia, and more than one complication were higher in the patients who experienced progression; conversely, the mean L3 SMI, platelet count, ALT, sodium, and AFP were lower (p < 0.05). The gene discussed is IL6; the disease is sarcopenia.