Univariate analysis revealed sarcopenia, more than one complication (including gastroesophageal varices, hepatic encephalopathy, acute kidney injury, and infection), age, MELD score, CRP ≥ 20 mg/L, sodium < 135 mmol/L, platelet < 100 × 109/L and AFP < 6.2 mmol/L to be associated with 90 day progression in patients with ACLF (cut-off values of CRP, platelet, and AFP were analyzed by ROC curve analysis). The gene discussed is AFP; the disease is infection.