The addition of apples or phloretin to the diet decreased intestinal inflammation in rodents and, In vitro, phloretin reduced the secretion of pro-inflammatory cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in a colon carcinoma cell line [6, 7]. This evidence concerns the gene CCL2 and colon carcinoma.