Furthermore, P-Rex1, a gene associated with prostate cancer invasive growth and metastasis, was found to be involved in atorvastatin-induced P2X7 signalling. They quickly translocate in response to P2X7 signaling and are then mediated by non-HMG-CoA reductase-dependent effects of statins. This evidence concerns the gene P2RX7 and Familial prostate cancer.